DOI: 10.1093/ofid/ofag613 ISSN: 2328-8957
Demographic, Clinical, and Mycologic Differences Between Invasive Fungal Sinusitis and Pneumonia in Hematologic Malignancy
Simran Gupta, Tejas S Athni, Esther Arbona-Haddad, Inia Perez Villa, Alexis Liakos, Alexandra Tong, Maria Shehata, Carolyn Strauch, Muneerah M Aleissa, Alice Z Maxfield, Regan W Bergmark, Victor Kovac, Amy C ShermanAbstract
Among 132 patients with hematologic malignancies and invasive fungal disease, invasive fungal sinusitis was associated with greater dissemination, lower biomarker sensitivity, more diverse fungal pathogens, and higher rates of chronic rhinosinusitis and sinonasal defects than invasive fungal pneumonia. These findings suggest distinct clinical syndromes with different risk factors and diagnostic considerations.