DOI: 10.1126/science.1068883 ISSN:
Decoding the Patterns of Self and Nonself by the Innate Immune System
Ruslan Medzhitov, Charles A. Janeway- Multidisciplinary
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.