DOI: 10.1182/blood-2023-181141 ISSN: 0006-4971
Daratumumab for Refractory Autoimmune Leukopenia: A Case Report
Xiaoyang Wang, Michael Guo, Karen Seiter, Amir Steinberg, Fauzia Paracha, Christopher R. Reilly, Fouzia Alam Shakil, Delong Liu- Cell Biology
- Hematology
- Immunology
- Biochemistry
Autoimmune leukopenia is a rare disorder but may cause severe life-threatening infections. Here we report a case involving a 58-year-old male with a history of severe autoimmune leukopenia that was highly refractory to therapies targeting T and B linage cells but had a durable response to daratumumab. This case management suggested that targeting plasma cells may be considered for refractory autoimmune leukopenia.