CYTOHISTOPATHOLOGICAL CORRELATION OF ABNORMAL PAPANICOLAOU SMEARS : STUDY AT A TERTIARY CARE CENTER

Background: The standard screening test for detecting cervical lesions and cancer is a Papanicolaou (Pap) smear. Carcinoma of cervix is one of the leading cause of death of female population in developing countries. By virtue of its accessibility,cancer of cervix can be readily diagnosed even in its preinvasive stage. If treated in the earlier stages the patient can often be cured of the disease. This study aims to evaluate the prevalence of abnormal cervical cytology cases and its correlation with histopathological ndings. This was a retrospective study Materials and Methods: conducted in the Department of Oncopathology, Gujarat Cancer and Research Institute, Ahmedabad from January 2022 to December 2022 , in which all Pap smears were reported as per the 2014 Bethesda system.The histopathological diagnosis of the corresponding cervix biopsies (if done) were also listed and compared for concordance. A total number of 2755 smears studi Results: ed included normal 2470(89.7%), precancerous and malignant 193 (7%), and inadequate 92 (3.3%). 193 smears showing atypical and malignancy included atypical squamous cells of undetermined signicance (ASCUS) 57 (29.53%), atypical glandular cells,not otherwise specied (AGC,NOS) 23 (11.9 %), low-grade squamous intraepithelial lesion (LSIL) 4 (2.07%), high-grade squamous intraepithelial lesion (HSIL) 30 (15.54%) and malignant 47 smears (24.35%). Biopsies showed 100% accuracy in malignant lesions. Our study revealed a good correlation between Conclusion: Pap smear and biopsy. Pap smear test was found to be equally sensitive to histopathological examination for the early detection of different cervical lesions.