DOI: 10.1039/d6dt02221a ISSN: 1477-9226
Cyclometalated iridium(
iii
) complexes conjugated with clofibrate and gemfibrozil: design, synthesis, and antitumor activity
Zheng Zhang, Yong-Sheng Yang, Meng-Ting Xu, Rong Duan, Ji-Xin Jiang, Rong-Tao Li, Rui-Rong Ye Ir(
iii
)–CA/GFB complexes activated PPARα and targeted mitochondria, triggering apoptosis and pyroptosis. This dual effect induced ICD, marked by ATP secretion, CRT externalization, and HMGB1 release, thereby promoting antitumor immunity.