Cu‒Catalyzed Cross‐Coupling reactions of Enamines and Terminal Alkynes: Access of Propargylamines as Neurodegenerative Disorder Agents

Reactions between enamine analogues and terminal alkynes were explored. Copper(I) complex of 1,10‐phenanthroline catalyzed these reactions to generate a diastereoselective propargylamines via C‒C bond formation. In the presence of Zn2+, the chiral propargylamines converted into the β‐allenoates with an excellent yield and enantioselectivity achieved up to 99%. Models of synthesized propargylamines were used for molecular docking and dynamic simulations, which indicate that this class of molecules shows promise for anti‐neurodegenerative activity.