Cryolipolysis of the Arms and Inner Thighs Shows Similar Treatment Outcomes in Chinese Individuals Compared to White Individuals Treated in a Prior Study: The XinCOOL Study
Jason K Rivers, William McGillivray, Martin Braun, Meetu Bhogal, Suzanne Zheng, Matthew Hickling- General Medicine
Abstract
Background
Studies of predominantly White participants show that cryolipolysis reduces subcutaneous fat in arms and inner thighs, but none have specifically tested for similar outcomes in participants of Chinese descent.
Objectives
This study assessed safety and effectiveness of cryolipolysis treatment for non-invasive subcutaneous fat reduction of arms and inner thighs in participants of Chinese descent to assess equivalence to results seen in a prior study of White participants.
Methods
Replicating a similar study design, participants of first- or second-generation Chinese descent underwent cryolipolysis treatment of arms and/or inner thighs. Effectiveness was assessed using pre- and post-treatment photographic review by blinded, independent experts, investigator-assessed caliper measurements, and participant satisfaction 12 weeks post-treatment. Safety was assessed throughout.
Results
Among 50 enrolled participants, 48 completed the study. The majority of participants (97.9%) were female, with a mean age of 36.0 years and mean BMI of 24.16 kg/m2 (range 19.3-29.9 kg/m2). Overall, 76.4% and 70.0% of pretreatment photographs of arms and pairs of inner thighs, respectively, were correctly identified by at least 2 of 3 reviewers. The mean reduction from baseline in caliper-measured fat thickness was 6.5 mm for arms and 6.6 mm for inner thighs, and the majority of participants (> 60%) were satisfied with treatment. No adverse events were reported.
Conclusions
Cryolipolysis is a well-tolerated, effective means of non-invasive fat reduction of arms and inner thighs in participants of Chinese descent. The results from this study show similar effectiveness and safety in Chinese participants compared to White participants treated in a prior study.