Crude Tieguanyin Oolong Tea Polysaccharides Regulate Intestinal Immune and Gut Microflora in Dextran Sulfate Sodium Induced Mice Colitis Crude Tieguanyin Oolong Tea Polysaccharides Alleviate Colitis

Background

The global incidence and prevalence of inflammatory bowel diseases (IBD) have been on the rise. Epidemiological studies, clinical trials, and animal experiments have indicated a negative association between the consumption of tea and IBD. This study aims to investigate the protective effects of crude Tieguanyin oolong tea polysaccharides (CTPS) on experimental colitis, while also exploring the underlying mechanisms.

Results

The administration of CTPS exhibited significant alleviation of IBD in the mice model, and was found to regulate T cell‐mediated immune responses in the colon by modulating cytokine production associated with T cells. Furthermore, CTPS demonstrated a positive impact on the gut microbiota, reversing the increase of pathogenic Helicobacter and enhancing the relative abundances of beneficial bacteria such as Akkermansia, Lachnospiraceae, and Odoribacter. Additionally, oral administration of CTPS led to an improvement in intestinal metabolism, specifically by increasing the levels of short‐chain fatty acids.

Conclusion

This study provides the first in vivo evidence of the protective effects of CTPS on colitis in mice. The effects are likely mediated through the regulation of T cell‐mediated responses and modulation of the gut microbiota, suggesting that CTPS may be a potential preventive and therapeutic approach for IBD.

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