S. Zielen, S. W. Bender, W. Kreuz, H. ‐G. Posselt, E. Solem, I. Scharrer

Crohn's Disease Activity

  • Gastroenterology
  • Pediatrics, Perinatology and Child Health

Summary:Twenty‐eight patients (mean age 13.5 years) with proven Crohn's disease were examined for factor VIII coagulation activity (VIII:C), factor VIII‐related antigen (VIII R:Ag), and factor VIII‐related ristocetin cofactor activity (VIII R:RCF). The factor VIII coagulation proteins were correlated with disease activity index according to van Hees and were compared with inflammatory parameters such as erythrocyte sedimentation rate, c‐reactive protein, and orosomucoid. Among the factor VIII proteins, factor VIII‐related protein (VIII R:Ag) correlates best with van Hees disease activity index, orosomucoid, c‐reactive protein, and erythrocyte sedimentation rate (p < 0.001 for all parameters). Since acute phase proteins are produced by liver cells, whereas VIII R:Ag is synthesized by endothelial cells, we postulate that this coagulation factor is highly sensitive in reflecting the inflammatory process in the intestine.

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