DOI: 10.1039/d6ra04693b ISSN: 2046-2069
Coumarin-based dual kinase inhibitors targeting CDK6 and VEGFR-2: experimental and computational validation
Hazem Elkady, Walid E. Elgammal, Ibrahim H. Eissa, Dalal Z. Husein, Hanan A. Al-ghulikah, Ghalbaa N. Alshahrani, Fatma G. Amin, Ahmed M. Metwaly, Eslam B. ElkaeedA novel coumarin derivative (7e) was identified as a dual CDK6/VEGFR-2 inhibitor with potent enzymatic activity, apoptosis induction, cell cycle arrest, and anti-migratory effects, supported by docking, molecular dynamics, and DFT studies.