CORRELATIVE STUDY OF SERUM URIC ACID AND CALCIUM WITH ADVANCING STAGES OF CHRONIC KIDNEY DISEASE

Introduction: CKD resulted in 1.2 million deaths in 2017 and was the 12th leading cause of death worldwide. In this study role of serum calcium and serum uric acid in the pathogenesis ofvarious stages of CKD and ESRD on dialysis will be ascertained.The role of these parameters as biomarkers of CKD can be used for the prevention, diagnosis, staging, and treatment of the disease. It is a hospital-based Materials And Methods: observational study.Group A consisting of 50 patients were chronic kidney disease stages 3 and stage 4 patients attending OP at the Department of Nephrology. Group B 50 consisted of ESRD patients who were undergoing dialysis at the NEPHRO PLUS unit in Nephrology Department. The clinical parameters recorded during the study period were(mean ± Results: SD) serum calcium levels in CKD 3&4 stages cases were 9.08±0.54 mg/dl and in ESRD cases 7.78±0.61 mg/dl and The(mean ± SD)serum uric acid levels in CKD stages 3&4 cases were 6.02±1.75mg/dl and in controls 6.95±1.89mg/dl. There is a high statistical signicance in the serum calcium level between the two groups. Conclusion: In this study, serum uric acid is signicantly increased and serum calcium is signicantly reduced in ESRD patients when compared to CKD stage 3,4 patients.