CORRELATION OF SERUM URIC ACID LEVELS WITH MATERNALAND PERINATAL OUTCOMES IN ANTENATAL FEMALES WITH PREGNANCY INDUCED HYPERTENSION

Introduction: Hypertensive disorders are the most common medical complications of pregnancy rampant globally. Of the Hypertensive disorders of pregnancy, preeclampsia complicates 2-8% of all pregnancies. Kidneys are the most commonly affected organ and hyperuricaemia is the earliest indication of a change in renal function and predates the onset of heavy proteinuria and severe hypertension. Material And Methods: 150 cases with pregnancy induced hypertension admitted in department of Obstetrics and Gynaecology, SRMSIMS, Bareilly from November 2018-May 2020 were studied for correlation of rising levels of serum uric acid with maternal and fetal outcomes and the severity of disease progression was observed. Results: Majority of the antenatal women among the study population were unbooked primigravidas with mean age 24.9 ± 4.5 years and 10.7% women had family history of hypertension. Maternal outcomes in respect to abnormal fundoscopy, abnormal liver and renal function tests were more deranged when serum uric acid concentration was above 5.5 mg/dL and this was statistically signicant. Similarly, there was a statistically signicant difference when fetal parameters were studied in terms of APGAR at <7 mins, NICU admission, intrauterine fetal demise, prematurity and low birth weight with signicant p value of 0.0053, 0.0152, 0.0024, 0.0415 and 0.0105 respectively at serum uric acid concentrations of <3.5, 3.5-5.5 and >5.5 mg/dL. Conclusion: Serum uric acid levels in patients with preeclampsia are associated with severity of the disease. Higher serum uric acid levels in pregnancy induced hypertension indicates heightened risk of progression to adverse maternal and perinatal outcomes.