Anjani Gupta, Supriya Papaiah, Anuradha Calicut Kini Rao, Renuka Patil

CORRELATION OF AUTOMATED HEMATOLOGY ANALYZER GENERATED RBC INDICES AND HISTOGRAM WITH MANUAL PERIPHERAL SMEAR EXAMINATION IN ANEMIA

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Background: Anemia is a common medical condition, mostly diagnosed in developing nations. Peripheral smear examination is the gold standard for diagnosing most RBC disorders, which may fail to get diagnosed by automated cell counters. Few studies exist that compare automated analyzer based histogram, complete blood counts (CBC) parameters with peripheral smear examination. Present study was carried out to correlate these parameters. Objectives: The current study was conducted with the aim to correlate RBC indices and histograms obtained from automated analyzer with peripheral smear examination in cases of anemia. Materials And Methods: In the haematology laboratory, blood samples from 775 anemic patients were obtained during a six-month period. The haematology analyzer-based metrics (RBC indices & histogram) and the peripheral smear examination were used to type each blood sample for anemia. The acquired diagnosis was examined to determine the signicance of the mean difference in various parameters. Results: 775 cases examined on peripheral blood smear showed the highest number of cases to have Normocytic normochromic anemia (57%), followed by Microcytic hypochromic anemia (35%). Dimorphic anemia (4.3%), macrocytic anemia (3.1%) and haemolytic anemia (0.6%). Analysis by erythrocyte indices and histogram showed similar frequency of various types of anemia, however the percentages varied in individual methods. The correlation between the diagnosis made by these methods was statistically signicant, p<0.0001. Conclusion: Histogram based data provide early intimation of subtle changes in numerical parameters, subjective to evaluation. RBC histogram and indices should be interpreted in the light of peripheral smear

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