CORRELATION BETWEEN VASCULAR CALCIFICATION AND UROLITHIASIS AMONGST NON-DIABETIC YOUNG KIDNEY STONES FORMER AND ITS ASSOCIATION WITH TYPES OF STONES

Introduction: As per recent studies, an association between nephrolithiasis and cardiovascular disease is present, due to an unknown cause. The study hypothesizes that vascular calcication is common in young nondiabetic kidney stone formers and is mostly associated with calcium types of stones. It should be investigated, whether the young nondiabetic kidney stone formers have vascular calcication and whether calcium stones conrmed on stone analysis are related to vascular calcication in kidney stone formers. Methods: A matched case-control study that kidney stone formers attending in Department of Urology in GMCH, Guwahati from 2021 to 2022. Age and sex-matched nondiabetic stone formers without vascular calcication on CT were drawn. A total of 390 patients were investigated, of which 129 were kidney stone formers with vascular calcication and 261 were kidney stone formers without vascular calcication. We used computed tomography imaging for Abdominal aortic calcication and stone analysis for the type of stone. The prevalence, severity, and associations of abdominal aortic calcication were compared between calcium kidney stone formers with vascular calcication and kidney stone formers without vascular calcication. Mean age was 32 years in non-diabe Results: tic calcium kidney stone formers with vascular calcication and 28 in abdominal aortic calcications without vascular calcication. Men represented 17.17% and 82.82% of calcium kidney stone formers with vascular calcication and abdominal aortic calcications without vascular calcication, respectively. A multivariate model adjusted for age, sex, high BP, diabetes, smoking status, and eGFR conrmed that calcium kidney stone formers have higher abdominal aortic calcication compared with other stone formers. 71.4% of patients have calcium stones on stone analysis. This study shows that Conclusions: young nondiabetic patients with calcium kidney stones suffer from signicantly higher degrees of aortic calcication than age- and sex-matched other stone formers, suggesting that vascular calcication may explain reported associations between nephrolithiasis