Correlation Between Serum Uric Acid–Creatinine Ratio Status and Renal Function in Hypertensive Nigerian Adults: A Hospital-Based Cross-Sectional Study
OE Obianyido, HO Obianyido, AE Onovo, UC Okechukwu, VC Ikekpeazu, CR Onwasigwe, JE Ikekpeazu, JC OkworBackground:
The serum uric acid-to-creatinine (SUA/Cr) ratio is emerging as a promising marker of renal metabolic status in hypertension; however, its relationship with renal function in Nigerian populations remains poorly understood.
Aim:
To evaluate the correlation between SUA/Cr ratio status and renal function in hypertensive Nigerian adults.
Methods:
This hospital-based, cross-sectional analytical study recruited 272 age and sex matched respondents. They were made up of 68 male and 68 female patients clinically diagnosed with hypertension, and 68 male and 68 normotensive individuals recruited as controls. Anthropometric indices were measured according to WHO-standardized protocols. Five milliliters of venous blood were drawn per respondent for biochemical analysis, which was analyzed using standard laboratory procedures. Pearson correlation analyses were employed to ascertain the association between hypertension parameters and renal function markers.
Results:
Hypertensive participants exhibited significantly higher serum creatinine levels and lower estimated glomerular filtration rate (eGFR) compared with normotensive controls (0.98 ± 0.44 mg/dL vs. 0.81 ± 0.18 mg/dL; 85.00 ± 23.40 mL/min/1.73 m² vs. 98.29 ± 20.70 mL/min/1.73 m², respectively;
Conclusion:
SUA/Cr provides clinically relevant insight into early hypertension-related renal changes and could serve as an accessible adjunct marker in renal risk assessment.