Correlation between Osteoprotegerin OPG Gene Polymorphisms (rs3102735 and rs2073617) and Susceptibility to Pediatric Chronic Kidney Disease in the Karbala Province
Rashad Rasheed Jawad, Hasanain Khaleel Shareef, Suhayr Aesa Al-QaysiAbstract
Background:
Patients with chronic kidney disease (CKD) have higher levels of osteoprotegerin (OPG), and these levels rise as renal function declines. Data on the relationship between OPG and renal function in the general population, however, are scarce.
Objective:
Our study aims to investigate the role of
Materials and Methods:
Blood samples were collected from 42 patients with chronic kidney disease, and 35 healthy as a controls group. Patients were diagnosed clinically by the specialized physician and computed tomography (CT) scan, in addition to use laboratory examination for urea and creatinine. The genotyping was carried out by using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique.
Results:
The GG, GA, and AA genotypes frequencies of rs2073617 were 19.05%, 50.0% and 30.95%, respectively, in the case group, and 25.7%, 61.85%, and 11.42%, respectively, in the control group. The CC, CT, and TT genotypes and C and T distributions of alleles of rs3102735 revealed no changes between the case and control groups that were statistically significant, and their carriers had a low risk of contracting an illness.
Conclusions:
The findings of this study show that