Copper(I)-NHC-Catalyzed Enantioselective Silylation of Alkenylphosphine Oxides.

A general method for enantioselective silylation of both aromatic and aliphatic α,β-unsaturated phosphine oxide derivatives remains elusive. Herein, we report a versatile enantioselective conjugate silylation protocol enabled by a newly developed N-heterocyclic carbenes. Under copper(I)–YC-NHC7 catalysis, a wide range of aromatic and aliphatic alkenylphosphine oxides undergoes efficient conjugate silylation, affording structurally diverse β-silylated alkylphosphine oxide derivatives with moderate to high yields and enantioselectivities.