DOI: 10.1039/d6ra05856f ISSN: 2046-2069
Continuous local minocycline delivery from PLA nanosphere-coated dental implants with long-term antibacterial activity and biocompatibility
Napossorn Patiyananuwat, Chalaisorn Thanapongpibul, Panarin Chinavinijkul, Bongkot Phumkrachai, Chinnadit Ngamwongronnachai, Salunya Tancharoen, Norased NasongklaA PLA-NS/MC layer-by-layer coating enables prolonged local minocycline delivery from titanium dental implants, maintaining antibacterial activity against P. gingivalis for more than 12 weeks while preserving biocompatibility and osseointegration.