Consumption of antibacterial drugs in pediatric multi-field hospital

Objective. To analyze consumption of antibacterial drugs in real clinical practice of pediatric hospitals. Material and methods. We analyzed consumption of antibacterial drugs in a multi-field pediatric hospital over a calendar year using the Anatomical Therapeutic Chemical/ Defined Daily Dose (ATC/DDD) methodology. For qualitative assessment of antibacterial drugs, we calculated a combined indicator including DDD/100 days and Antibiotic Spectrum Coverage (ASC). Next, consumption of antibacterial drugs in each department was analyzed depending on antibiotic spectrum in three categories: narrow (ASC <6), intermediate (6–10), and wide (>10). Results. Median DDD/100 days was 31.53 [16.76; 39.9] per year in the hospital. According to DU90% analysis, third-generation cephalosporins (J01DD) were the most common group of antibiotics (with ceftriaxone predominating). Incidence of its consumption varied across departments. Analysis of consumption of antibacterial drugs in each department showed that intermediate-spectrum antibiotics predominated. Conclusion. High consumption of antibacterial drugs in certain hospital units was revealed. Third-generation antibiotics were the most common. Advisability of ASC-based comprehensive assessment of antibacterial drug consumption was demonstrated.