DOI: 10.1097/md.0000000000041047 ISSN: 1536-5964

Construction of a predictive model for type 2 diabetes mellitus with coexisting hypertension: A cross-sectional study

Huiling Zhang, Shuang Yu, Zheyuan Xia, Yahui Meng, Dezheng Zhu, Xiang Wang, Hui Shi

Type 2 diabetes mellitus (T2DM) and hypertension often coexist, raising the risk of cardiovascular events, renal disease, and mortality. Early identification of high-risk patients with T2DM and concurrent HTN is vital for personalized care. This study aims to construct and validate a predictive model for hypertension in T2DM patients to aid early intervention and tailored treatment. A quantitative observational study using multivariable logistic regression analysis was conducted, with results presented in a nomogram. Data from 423 T2DM patients (206 with hypertension and 217 without) hospitalized at a tertiary hospital in Anhui Province between February 2023 and February 2024 were analyzed. Univariate and multivariate logistic regression identified significant predictors, and model performance was evaluated via ROC curves, AUC values, and the Hosmer–Lemeshow test. Age, alcohol use, diabetic nephropathy, coronary heart disease, cerebral infarction, and body mass index were significant predictors. The model showed good performance with an AUC of 0.72, and the Hosmer–Lemeshow test (P = .074) confirmed its fit. The predictive model effectively identifies high-risk T2DM patients for hypertension, aiding early intervention and personalized treatment.

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