D. H. Van Thiel, J. S. Gavaler, A. B. Zajko, C. F. Cobb

Consequences of Complete Bile

  • Gastroenterology
  • Pediatrics, Perinatology and Child Health

SummaryPrepubertal male rats underwent bile duct ligation or a sham operation. Sham operated animals were divided into two groups: isocalorically fed (matched to the bile duct ligated animals) and adlibitum fed animals. At 60 days of age (after puberty in a male rat) all animals were killed. Bile duct ligated animals had larger livers, greater bilirubin, greater bile acid, greater aspartate transaminase, and greater alkaline phosphatase levels and lower testosterone and luteinizing hormone levels in their serum than did the controls. Moreover, the testes and seminal vesicles were smaller in the bile duct ligated animals than in the controls. These data suggest that chronic cholestasis contributes, at least in part, to the pubertal and maturational failure that occurs with the chronic cholestatic diseases of childhood.

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