DOI: 10.1039/d4md00055b ISSN: 2632-8682
Computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
Herein, we developed innovative EGFR inhibitor using the FBDD approach. Compound 30a emerged as highly potent, selective, capable of arresting the cell cycle, and inducing apoptosis, underscoring its potential as a novel anticancer therapeutic agent.