DOI: 10.3390/ijms27219474 ISSN: 1422-0067
Comprehensive Genomic Profiling of Relapsed Interdigitating Dendritic Cell Sarcoma Reveals Novel Molecular Insights in a Patient Achieving Durable Remission After Autologous Stem Cell Transplantation
Costantino Riemma, Chiara Cavatorta, Chiara Salvesi, Jessica Garbetta, Davide Angeli, Eugenio Fonzi, Federico Lo Schiavo, Chiara Molinari, Giorgia Simonetti, Francesco Malaspina, Jessica Rosa, Gerardo Musuraca, Anna FerrariInterdigitating dendritic cell sarcoma (IDCS) is an extremely rare hematologic malignancy with no standardised therapeutic approach, particularly in the relapsed setting. We report a case of a 69-year-old woman with multifocal relapsed IDCS, KRAS/BRAF/SMARCA4 mutated, successfully treated with CHOP chemotherapy followed by consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT), achieving a durable complete remission. This case supports the potential role of intensive chemotherapy and ASCT in selected patients with aggressive or relapsed disease.