Complete response of multicentric reticulohistiocytosis treated with tofacitinib

In this paper, we report a case of a multicentric reticulohistiocytosis with articular and skin manifestations that didn’t respond to classical treatments. Tofacitinib was prescribed and a complete clinical resolution was achieved. We discuss the risk of starting a JAKi treatment in a multicentric reticulohistiocytosis due to a possible malignancy-association with it.