DOI: 10.1002/mrc.70152 ISSN: 0749-1581
Complete NMR Structural Elucidation, Conformation, and Cytotoxic Evaluation of Polystachyne I, a New neo ‐Clerodane Diterpenoid From Salvia polystachya
Miguel A. Fuentes‐Figueroa, Ana K. Tinajero‐Acevedo, Susana Madrigal‐Ortiz, Jennifer Alexis Rojas‐Morales, Rubén A. Toscano, Omar Cortezano‐Arellano, Mabel Fragoso‐Serrano, Luis A. Salazar‐Olivo, Itzi Fragoso‐Martínez, Rogelio Pereda‐Miranda, Elihú BautistaABSTRACT
Chemical investigation of the aerial parts of Salvia polystachya Ortega afforded a new neo ‐clerodane‐type diterpenoid named polystachyne I ( 1 ) and the previously known diterpenoid microphyllandiolide ( 2 ). Their structures were elucidated by 1D and 2D NMR experiments. The absolute configuration of 1 was established by single‐crystal X‐ray diffraction. Compound 1 was tested for cytotoxicity against three human cancer cell lines, showing moderate activity.