DOI: 10.4103/mjbl.mjbl_1683_23 ISSN: 1812-156X
Comparison Study Between Captopril and Crataegus azarolus to Alleviate Cardiovascular Dysfunction in Male Rabbits
Ali Jasim Muhammed Alkhafaji, Ahmed Samir Abukhomra, Zahid Mohammad Kadhim, Noor R. Abady, Adnan Mansour Jasim Abstract
Background:
High blood pressure (BP) poses a significant risk for various severe health conditions, including angina Pectoris, brain stroke, kidney damage, atherosclerosis, and vision impairment. Addressing this issue is crucial in preventing these cardiovascular complications.
Objective:
This study aimed to evaluate the potential of hydroalcoholic extracts from
Crataegus azarolus
(wild hawthorn fruits) in mitigating cardiovascular damage induced experimentally in male New Zealand rabbits. Understanding the affinity of Cianidanol and Apigenin to antagonist angiotensin-converting enzyme (ACE) receptors or inhibitors to peptidyl-dipeptidase A, kininase II, EC. 3.4. 15.1 receptor is leading to identified new compound suitable for controlling hypertension and aiding in regulating many cardiovascular problems.
Materials and Methods:
The current study was designated to check drug docking study, and use the program to understand the ability of active compounds from (wild hawthorn fruits) to inhibit or block ACE. The
in vivo
study was done by following. The albino male rabbits (24) were distributed at random and divided into four equal groups. The initial group represents the placebo group (negative control group), the next second group received intravenous phenylephrine to generation defect hypertension along with hyperlipidemic dietary habits, the third group received hawthorn extract, while the fourth group administered captopril treatment. Over the period of 5 weeks, the investigators evaluated lipid profile alterations, and antioxidant activity.
Results:
Molecular docking results showed there is a good affinity between binding affinity Cianidanol and Apigenin to antagonist ACE receptor as compared with captopril suggesting a potent inhibitory of ACE R than captopril. The
in vivo
study confirmed a significant elevation in rabbits’ serum superoxide dismutase and catalase and a reduction in malondialdehyde levels with wild hawthorn administration. Additionally, the hawthorn extract results in accelerate reduce lipid profiles from the side and increased high-density lipoproteins. Herein, treatment results in a clear reduction of nitric oxide levels from the side and lowered serum troponin I, as well as superior to Captopril in some aspects.
Conclusion:
The program study drug docking, confirmed acceptable data to explain the efficacy of the main active compound from extract
C. azarolus
to affinity and block ACE R, as well as support this study by
in vivo
data from lipid profile as well as antioxidant and anti-inflammatory markers.