DOI: 10.1177/09733698261473046 ISSN: 0973-3698

Comparison of Clinical Characteristics and Outcomes of Systemic Lupus Erythematosus-associated Thrombotic Thrombocytopenic Purpura and Idiopathic Thrombotic Thrombocytopenic Purpura: A Single Centre Study from Eastern India

Alekhya Amudalapalli, Abhichandra Maddineni, Rasmi Ranjan Sahoo, Ashlesha Shukla, Sandeep Nagar, Roshani Sridhar, Pritish Chandra Patra, Sumanth Madan, Gargi Sasmal, Pradeepta Sekhar Patro
Show PDF Cite

Objective:

To investigate the clinical characteristics and outcomes of thrombotic thrombocytopenic purpura (TTP) in patients with systemic lupus erythematosus (SLE) compared to idiopathic TTP (I-TTP).

Methods:

This retrospective cohort study included adult patients with SLE-TTP ( n = 9) and I-TTP ( n = 7) treated at a tertiary care centre in East India from January 2019 to July 2024. Patients with SLE-TTP fulfilled the 2019 American College of Rheumatology criteria for SLE, and TTP was defined if microangiopathic haemolytic anaemia and thrombocytopenia (platelet count <100,000 cells/µl) were present with an intermediate-to-high-risk PLASMIC score. Clinical characteristics, treatment details and outcomes were extracted from medical records. Treatment response was assessed using complete remission criteria and survival analysis.

Results:

The SLE-TTP group consisted of all female patients with a median age of 27 years, significantly younger compared to the I-TTP cohort (median age of 55 years, P = .01). Haematological parameters were comparable between groups. Complete response rate was achieved in eight out of nine patients (89%) in SLE-TTP and five out of seven patients (71%) in the I-TTP group ( P = .4). The median time to complete response was 27 and 45 days for SLE-TTP and I-TTP groups, respectively ( P = .31).

Conclusion:

SLE-TTP patients were younger at diagnosis compared to I-TTP. The findings are exploratory, and further research with a larger sample size and additional biomarkers is warranted to enhance understanding and management of SLE-TTP and I-TTP.

More from our Archive