Comparison of Blood Glucose Values Used for Impending Non-Severe Hypoglycemia Management with Corresponding Continuous Glucose Monitoring Data in Type 1 Diabetes: A Secondary Analysis of the REVERSIBLE Trial
Andréanne Marquis, Ran Cheng, Sara Al-Mahayni, Ahmed Osman, Josephine Molveau, Virginie Messier, Rémi Rabasa-Lhoret, Nadine TalebBackground:
To assess continuous glucose monitoring (CGM) data corresponding to blood glucose (BG) values used for impending non-severe (NS) hypoglycemia management in people living with type 1 diabetes (PwTID).
Methods:
We performed a secondary analysis of the REVERSIBLE trial, a three-arm open-label crossover study assessing the efficacy of 16 g oral carbohydrates (CHO) for preventing NS hypoglycemia at different BG levels: <72 mg/dL (4 mmol/L, level 1), ≤80 mg/dL (4.5 mmol/L), or ≤90mg/dL (5.0 mmol/L). CGM data (DexcomG6 ® ) were compared with BG to assess their variances and mean absolute relative differences (MARDs).
Results:
In all three arms CGM values overestimated BG levels (
Conclusion:
When using CGM, PwTID may need to treat or prevent NS hypoglycemia at a higher threshold than 72 mg/dL (4.0 mmol/L) and 80 mg/dL (4.5 mmol/L), respectively.