Comparative evaluation of the efficacy of 0.2% hyaluronic acid gel and ozonated oil in wound healing following laser-assisted depigmentation
Fathima Suharal, Nagalapuram Bendict, Praveen Kumar Seelam, Anil Kumar Kancharla, Nandigam Anwesh Reddy, Mohammad Sheema TasneemAbstract:
Background:
Gingival hyperpigmentation affects smile esthetics and patient confidence. Laser-assisted depigmentation is an effective treatment; however, optimal postoperative wound healing and pain management are essential. Adjunctive agents such as ozonated oil, which possesses antimicrobial and regenerative properties, and 0.2% hyaluronic acid (HA) gel, which supports tissue repair, may enhance postoperative recovery. This study aimed to compare their effects on wound healing and pain perception following gingival depigmentation.
Materials and Methods:
A split-mouth, randomized study was conducted on 25 systemically healthy individuals undergoing diode laser depigmentation (800 nm, 1 W) under topical anesthesia. One site (Group A) was treated with 0.2% HA gel, whereas the contralateral site (Group B) received ozonated oil. Wound healing and pain perception were evaluated on postoperative days 3 and 7, while repigmentation was assessed at 3 months.
Results:
Group A (0.2% HA gel) demonstrated significantly greater improvement in wound healing compared with Group B. Conversely, Group B (ozonated oil) showed a significantly greater reduction in postoperative pain scores. No repigmentation was observed at either site during the 3-month follow-up period.
Conclusions:
Topical 0.2% HA gel enhanced wound healing more effectively following laser-assisted depigmentation, whereas ozonated oil was superior in reducing postoperative pain. These findings suggest that the use of these adjunctive agents may help optimize wound healing and patient comfort following esthetic periodontal procedures.