Comparative Effect of Pregabalin and Lavandula angustifolia on Behavioral Changes in Rats’ Model of Epilepsy
Zahraa Ahmed Hussein, Reyadh H. Al-Mosawi, Mufeed Jalil EwadhAbstract
Background:
Linalool is an aromatic monoterpene alcohol widely found in essential oils. Linalool is one of the main bioactive components of
Objectives:
Explore the potential anti-epileptic activity of
Materials and Methods:
Twenty-five adult Wistar albino male rats, aged about 12 weeks old and weighing between 300 and 350 g were gathered and habituated in an animal house of the College of Medicine, Babylon University. Rats were divided into five groups as follows: Group 1: control group, Group 2: PTZ, Group 3: Pregabalin + PTZ. Group 4: Linalool + PTZ, Group 5: the combination group, Pregabalin + Linalool + PTZ.
Results:
In Groups 3: Pregabalin + PTZ (12.8 mg/kg + 40 mg/kg), Group 4 Linalool + PTZ (300 mg/kg + 40 mg/kg), Group 5: the combination group, Pregabalin + Linalool + PTZ (12.8 mg/kg + 300 mg/kg + 40 mg/kg). The results showed a significant increase in latency and decreases in duration and severity of epilepsy compared to group 2 (PTZ group).
Conclusion:
Behavioral changes (decreasing latency period, increasing severity and duration of fits) induced by pentylenetetrazole were found to be opposed by linalool, pregabalin, and a combination of linalool with pregabalin via attenuating the severity and duration of fits, and by increasing the latency period of fits in male rats.