DOI: 10.1039/d5ra08513f ISSN: 2046-2069
Comparative binding and activity analysis of known serine hydroxymethyltransferase inhibitors in biochemical assays
Julian Gräb, Christine Wagner, Charlotte Beber, Jennifer Szczesny, Stefan Rubner, Ioannis PapasotiriouThis study presents a comparative biochemical characterization of known SHMT inhibitors and thereby introduces a new methodological strategy for a cost-effective coupled enzymatic assay to analyze SHMT inhibition.