DOI: 10.17140/poj-7-e015 ISSN: 2471-142X
Comments on Acute Pancreatitis’ Progression Hypotheses to Chronic Pancreatitis
Lorenzo DioscoridiFrom our experience and several research studies, acute pancreatitis (AP) progression to chronic pancreatitis (CP) is a complex issue in the medical field. The progression was hypothesized many years ago but still, many controversies are not clarified in the present literature. CP is a well-known invaliding disease that causes a sensitive decrease in life expectancy. This pathology is associated with several genetic alterations that can provoke morphological abnormalities.1 On the other hand, AP is a syndrome (and it must be considered more a systemic than confined pathology) caused by the release of pancreatic enzymes into the bloodstream and subsequent activation of systemic inflammatory systems (as complements).2