Comment on “Solubility Behavior of Meglumine Form I in 12 Pure Solvents: Experimental Measurements, Thermodynamic Modeling, And Solvation Mechanism Analysis”

Abstract

Recently, Jia and his research team published an academic paper titled “Solubility Behavior of Meglumine Form I in 12 Pure Solvents: Experimental Measurements, Thermodynamic Modeling, And Solvation Mechanism Analysis.” in this journal, correlating the experimental data with three thermodynamic models (modified Apelblat equation, λh equation, and van’t Hoff equation). However, verification indicates that the parameters of the modified Apelblat and van’t Hoff models reported in the original paper are incorrect, leading to significant deviations between the calculated and experimental solubility values, even order-of-magnitude differences in some solvent systems. This commentary first verifies the errors of the original model parameters and quantifies the deviations. The modified Apelblat and van’t Hoff models are then refitted using the original experimental data, obtaining corrected parameters with average relative deviations (ARD) of 1.91% and 2.11%, respectively. The λh model parameters in the original work are relatively reliable and do not require refitting. Additionally, possible causes of the fitting errors in the original study are analyzed, including unspecified adoption of scaled solubility data for model fitting and insufficient decimal places of fitting parameters. The corrected model parameters provided herein can offer reliable thermodynamic data for the crystallization, formulation development, and industrial application of Meglumine Form I and also remind researchers to pay attention to data accuracy in thermodynamic fitting studies.