DOI: 10.1039/d4gc02524e ISSN: 1463-9262
Comment on “l -Proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: regioselective synthesis of 5-arylpyrimido[4,5-b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in wate
Ting Chen, Syrine Mahdadi, Stéphanie Desbène-Finck A one-pot synthesis of 5-phenyl-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione from barbituric acid, benzaldehyde, and aniline gave high yields. Structural analysis confirmed a linear structure, unlike Khalafi-Nezhad's report.