DOI: 10.1039/d4sc00720d ISSN: 2041-6520
Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis
James I. Bowen, Xiaotong Zhong, Kaining Gao, Benjamin Reed, Matthew P. Crump, Luoyi Wang, Christine L. Willis- General Chemistry
Integrating total synthesis with genetic engineering of Sorangium strains reveal insights into the enzyme-catalysed formation of the 20,21-alkene in ambruticin biosynthesis.