DOI: 10.1021/acs.orglett.6c02875 ISSN: 1523-7060
Co(II)-Catalyzed Intramolecular Carbocyclization of ortho -Alkynylaryl Vinylsilanes to Sila-exocyclic 1,3-Dienes
Luo Liu, Zilu Zhang, Fangsheng Huang, Huanfeng Jiang, Wei ZengAbstract
Exocyclic 1,3-dienes are often difficult to synthesize owing to their inherent thermodynamic instability. In this study, a Co(II)-catalyzed intramolecular carbocyclization of sila-enynes has been developed to afford benzosilole-fused exocyclic 1,3-dienes through a cascade oxidative cyclization, β-H elimination, and reductive elimination process. The resulting sila-exocyclic 1,3-dienes can serve as versatile platform molecules for further assembling high-value benzosilole derivatives.