DOI: 10.1021/acs.joc.6c01193 ISSN: 0022-3263
CoFe2O4–Catalyzed Three-Component One-Pot Synthesis of (2-Imino)-1,3-oxathioles
Hongzhi Qu, Rong Huang, Leling Zhang, Xirui Li, Ruini Ding, Fuhong Xiao, Guo-Jun DengAbstract
A convenient, one-pot synthesis of (2-imino)-1,3-oxathioles derivatives from readily available nitrobenzene, 2-naphthol, and carbon disulfide is developed, using magnetically separable CoFe2O4 as a heterogeneous catalyst. This three-component protocol enables efficient construction of the target heterocycles and allows for easy catalyst recovery and reuse via an external magnet. A range of substrates are well tolerated, affording the corresponding products in good yields.