DOI: 10.1093/jnci/51.2.703 ISSN: 1460-2105
Cocarcinogenic Agents in Tobacco Carcinogenesis,
B. L. Van Duuren, C. Katz, B. M. GoldschmidtSummary
Five cigarette smoke components were tested for cocarcinogenic activity; they were repeatedly applied to mouse skin together with a low dose of benzo[a]pyrene for 52 weeks. Pronounced activity was shown by catechol and the noncarcinogenic aromatic hydrocarbons pyrene, benzo[e]pyrene, and benzo[g,h,i]perylene. Phenol had a small inhibitory effect on benzolalpyrene tumorigenesis.