Co-trimerization of Benzonitriles with Guanidine Hydrochloride: Synthesis of 2-Bromo-4,6-Diaryl-1,3,5-Triazine Derivatives Bearing Electron-withdrawing Groups

Abstract

In recent decades, various types of aryl-substituted 1,3,5-triazine derivatives have been applied in many research fields, including biomedical chemistry, non-linear optics, and organic electronics. However, the substituent scope for 4,6-diaryl-1,3,5-triazines (DAr-TRZs) remains limited. Here, we present our work on the synthesis of 2-amino- and 2-bromo-DAr-TRZ derivatives bearing electron-withdrawing groups on the aryl rings. Our synthetic methods successfully provided trifluoromethyl-, nitrile-, and nitro-substituted DAr-TRZs. These triazines with highly electron-deficient nature will expand the structural diversity of conventional triazine-based functional materials.