Clinicopathological challenges of diagnosing reactive infectious mucocutaneous eruption

Reactive infectious mucocutaneous eruption (RIME) is a skin eruption. It is often mistaken for other conditions that are associated with more severe sequelae that require high-level care, including toxic epidermal necrolysis and multisystem inflammatory conditions. RIME mimickers and the poor specificity of pathology tests for infectious causes of RIME have made the diagnosis and management of this disease challenging. Children with a respiratory prodrome, in the absence of suggestive drug exposures and an acute onset mucosal eruption limited to <10% surface area, are likely to have RIME.