DOI: 10.1177/03000605261488117 ISSN: 0300-0605

Clinical value of global longitudinal strain in assessing left ventricular function and predicting cardiovascular hospitalization in patients with end-stage renal disease

Sudan Wang, Ang Li, Guiling Wei, Lu Li, Peng Miao, Hong Ye, Chunsun Dai, Zhuo Xu
Show PDF Cite

Objective

To assess the value of global longitudinal strain measured by speckle-tracking echocardiography in detecting early left ventricular dysfunction and predicting cardiovascular-related hospitalizations in patients with end-stage renal disease.

Design

This retrospective study included 271 inpatients with end-stage renal disease admitted from April to July 2024. Clinical, laboratory, and echocardiographic data were collected. Patients were grouped according to global longitudinal strain, and correlation analysis, logistic regression, and receiver operating characteristic analysis were performed to develop a cardiovascular risk prediction model.

Setting

The Second Affiliated Hospital of Nanjing Medical University.

Participants

A total of 271 inpatients with end-stage renal disease admitted from April to July 2024 were included in this study.

Results

The median global longitudinal strain was −16.3% and was negatively correlated with ejection fraction (R 2  = 0.132, P  < 0.0001). Among patients with preserved ejection fraction (≥50%), 48.12% had impaired global longitudinal strain. Global longitudinal strain was significantly associated with troponin I, pro-B-type natriuretic peptide, left atrial diameter, left ventricular end-diastolic diameter, and interventricular septal thickness. Global longitudinal strain was highest in the cardiovascular group, and the differences remained significant among patients with preserved ejection fraction. Global longitudinal strain independently predicted cardiovascular hospitalization (odds ratio = 1.10, 95% confidence interval: 1.02–1.18; P  = 0.0144). The cardiovascular hospitalization risk prediction model for patients with end-stage renal disease incorporating global longitudinal strain showed good performance, with areas under the curve of 0.787 for the base model and 0.811 for the extended model.

Conclusion

Global longitudinal strain is a sensitive indicator of early left ventricular dysfunction in patients with end-stage renal disease, particularly those with preserved ejection fraction, and is independently associated with cardiovascular-related hospitalization.

More from our Archive