Clinical study of butyrylcholinesterase and heparin binding protein as early markers of traumatic inflammation
Huiying Zhang, Hui Liu, Jianguo WangAbstract
Background
To observe the changes of butyrylcholinesterase (BChE) and heparin binding protein (HBP) in post‐traumatic inflammation, in order to determine whether they can be used as early diagnostic indicators of post‐traumatic inflammation.
Methods
Injury severity score (ISS) was used to evaluate the severity of trauma. The activity of butyrylcholinesterase in patients with traumatic injury with ISS ≤ 3 and ISS > 3 was detected, and the levels of related inflammatory biomarkers were detected. Sixty patients with trauma treated in our hospital from 01 to 08–2022 to 31‐10‐2022 were divided into control group (ISS ≤ 3) and damage group (ISS > 3) according to ISS. Another 30 cases of non‐invasive physical examination in the same period were selected as the normal group. BChE, HBP, white blood cell count (WBCC) and C‐reactive protein (CRP) were measured at T0, 1 h (T1), 2 h (T2), 3 h (T3), 4 h (T4) and 5 h (T5). The differences among the indexes were statistically analyzed.
Result
The BChE of patients with ISS > 3 decreased significantly at 1 h after admission, while the BChE of patients with ISS ≤ 3 had no significant change at 5 h. The HBP of the patients with ISS > 3 increased significantly at 1 h after admission, while the BChE of the patients with ISS ≤ 3 had no significant change at 5 h. There was no significant change in CRP and WBCC at 5 h.
Conclusion
The decrease of butyrylcholinesterase activity and the increase of HBP activity are the early indicators of acute systemic inflammation, which may be of great significance for the early diagnosis of traumatic systemic inflammation.
Trial registration
This study was registered on