Clinical Profile and Outcomes of Clostridioides Difficile Infection in Noninflammatory Bowel Disease Patients: A Retrospective Study from a Tertiary Care Center
Srinivas Gridhati, Sai Sarath Dasari, S. Shanmughanathan, A. K. Koushik, K. S. Sridharan, Sai Divija Kanuri, Ramanjaneya Reddy MedagamAbstract
Background:
Materials and Methods:
This retrospective study included 69 adult patients diagnosed with CDI between November 2024 and November 2025. Patients with inflammatory bowel disease, previous fecal microbiota transplantation, or incomplete records were excluded. Demographic, clinical, laboratory, and microbiological data were analyzed. Univariate and multivariate regression analyses were performed to identify the factors associated with prolonged hospital stay.
Results:
The mean age of the study population was 71.0 ± 16.4 years and males constituted 56.5% of patients. Hospital-acquired infection accounted for 89.9% of cases, whereas 10.1% were community-acquired. Diabetes mellitus was present in 76.6% of patients. Piperacillin–tazobactam and cephalosporins were the most frequently used antibiotics before diagnosis. The median duration of hospitalization was 15.4 days (interquartile range: 10–19 days). Mortality occurred in 2.9% of patients. Increasing age, diabetes mellitus, and prolonged antibiotic exposure before diagnosis were independently associated with prolonged hospital stay.
Conclusion:
Elderly patients with diabetes mellitus represented the majority of noninflammatory bowel disease patients with CDI. Hospital-acquired infection predominated, advanced age, diabetes mellitus, and prolonged antecedent antibiotic exposure were associated with prolonged hospitalization.