DOI: 10.4103/apc.apc_18_23 ISSN:

Clinical profile and outcome of cardiac manifestations in patients presenting with multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection

Gautam Singal, Akash Batta, Siddharth Bhargava, Sushil Kumar, Rohit Tandon, Anshuman Gupta, Abhishek Goyal, Shibba Takkar Chhabra, Naved Aslam, Gurpreet Singh Wander, Bishav Mohan
  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology and Child Health
Show PDF Cite

ABSTRACT

Multisystem inflammatory syndrome in children (MIS-C) can cause significant morbidity and mortality in children. This study was conducted to assess the pattern and outcome of cardiac abnormalities in MIS-C. This retrospective study was conducted in children with MIS-C between 1 month and 18 years. We enrolled 53 children with a mean age of 7.78 ± 4.62 years. Overall, 35.8% of children with MIS-C had cardiac manifestations in the form of coronary artery abnormalities (CAAs) or left ventricular (LV) dysfunction. Younger age (P 0.009) and high C-reactive protein at admission (P = 0.001) were significant predictors of cardiac involvement. CAAs were seen in 11.3% of children. On follow-up, 67% and 83% of children showed regression of CAA at 1 and 6 months, respectively. 24.5% of patients had presented with LV dysfunction. LV ejection fraction improved significantly at 1 month (P = 0.002) and 6 months (P = 0.001). Cardiac outcomes in MIS-C were favorable with timely identification and treatment.

More from our Archive