Clinical predictive modeling of CK-MB using troponin I/T and CPK in patients post myocardial infarction
Mohammed Alzain, Mohammed AlSieni, Mohamed Gamil Mehanna, Ryan Adnan Sheikh, Fahad A. Al-Abbasi, Abdulaziz Mohmmed Y. Alshamhani, Mohammed Abdullah Ali Alghamdi, Ujjwal Nautiyal, Vikas Kumar, Firoz AnwarAbstract:
INTRODUCTION:
Myocardial infarction (MI) continues to be a leading cause of global morbidity and mortality. This study evaluated the predictive relationships between Creatine Kinase-MB (CK-MB) and Troponin I/T (cTnI/T), creatine phosphokinase (CPK), and C-reactive protein (CRP) markers to improve clinical interpretation where CK-MB assays are unavailable.
MATERIALS AND METHODS:
A retrospective cohort of 102 first-time MI patients from multiple Saudi hospitals was analyzed. Demographic, biochemical, and clinical data were extracted, and univariable and multivariable linear regressions were performed via R (v4.4.2). Subgroup analyses by age, sex, and body mass index were conducted to explore demographic variations.
RESULTS:
Mean CK-MB levels were 60.85 ± 51.69 U/L in males and 53.71 ± 45.44 U/L in females. cTnI/T, averaged 7.87 ± 12.65 ng/mL, total CPK 370.85 ± 466.99 U/L, and CRP 22.09 ± 14.12 mg/L. Univariable regression revealed strong positive association of CK-MB with cTnI/T, (estimate = 2.98,
DISCUSSION AND CONCLUSION:
These findings support using cTnI/T and CPK as reliable clinical correlates for CK-MB estimation in post MI evaluation, especially when laboratory access is limited.