Clinical characteristics and in-hospital outcomes of patients with acute heart failure: baseline results from the turkiye heart failure (TURK-HF) registry
U Kocabas, I Ergin, T Kivrak, S Murat, S Gunay Polatkan, D Karabulut, B Murat, Z Ulutas, T S Tan Kurklu, V O Tanik, T Sen, O Birdal, M Demir, U Y Sinan, I TengizAbstract
Aim
This study aimed to evaluate the clinical characteristics and in-hospital outcomes of hospitalized patients with acute heart failure (HF).
Methods
The TURK-HF registry is a national, multicenter, prospective, ongoing, observational study of unselected patients with HF, regardless of ejection fraction (EF). A total of 51 investigators from 41 centers in 25 cities across Türkiye participated in the registry. A total of 415 patients with acute HF were enrolled between January and December 2025.
Results
The median age of the patients was 71 years, and 190 (45.8%) were female. Among the study population, 67.0% had HF with reduced EF, and 33.0% had HF with non-reduced EF. The proportion of patients with de novo HF was 20.4%. The most common clinical presentations were acute decompensated HF (72.3%), acute pulmonary edema (11.4%), and cardiogenic shock (4.1%) (Figure). The etiology of HFrEF was ischemic in 48.5% of patients, and 63.1% had a history of HF hospitalization. Most of the study population were New York Heart Association functional class III-IV (78.4%), and the mean EF was 36%. The most common comorbidities were hypertension (66.9%), diabetes (50.4%), atrial fibrillation (43.3%), and chronic kidney disease (34.3%). At the time of hospital admission, renin-angiotensin system (RAS) inhibitors, beta-blockers, mineralocorticoid receptor antagonists (MRAs), and sodium–glucose cotransporter 2 (SGLT2) inhibitors were prescribed to 57.9%, 70.8%, 38.0%, and 27.5% of the patients, respectively. During the hospitalization period, 20.4% of patients received noninvasive mechanical ventilation support, and 4.7% were intubated. Intravenous inotropes and vasopressors were administered to 13.9% and 9.0% of patients, respectively. The most common complications during hospitalization were acute kidney injury (23.3%) and systemic infection (19.8). The median length of hospital stay was 6 days. The in-hospital mortality rate was 3.5%.
Conclusion
The TURK-HF registry analysis provided comprehensive real-world data on the clinical characteristics and in-hospital outcomes of hospitalized patients with acute HF.
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