DOI: 10.1039/d6ra03722d ISSN: 2046-2069
Click chemistry-based synthesis of fluorescent digitoxin derivatives with anticancer activity and cellular imaging potential
Jiří Bejček, Michal Jurášek, Monika Kreisslová, Jan Škubník, Ivana Křížová, Jan Fähnrich, Soňa Gurská, Petr Džubák, Marián Hajdúch, Vojtěch Spiwok, Pavel Drašar, Tomáš Ruml, Silvie RimpelováFluorescent digitoxin derivatives prepared by click chemistry retain anticancer activity while enabling intracellular imaging, providing molecular tools to study digitoxin localization and supporting future targeted anticancer agent development.