M. Malathi, R. Prabhakaran, Arivudai Nambi, Bharathi Babu

CHRONOTHERAPY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ONCE DAILY SUSTAINED RELEASE THEOPHYLLINE VS THRICE DAILY STANDARD THEOPHYLLINE PREPARATION – AN OPEN LABEL STUDY.

  • General Medicine
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  • Ocean Engineering
  • General Medicine
  • General Medicine
  • General Medicine
  • General Medicine
  • General Earth and Planetary Sciences
  • General Environmental Science
  • General Medicine
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Chronic Obstructive Pulmonary Disease (COPD) is a long-term, progressive respiratory condition characterized by airow limitation in the lungs. There is a circadian variation in FEV1 in stable COPD peaking at 4:00 pm and dipping at around 4:00 am In patients who experience morning symptoms, the most common morning symptoms were coughing, shortness of breath, and sputum production. Research has indicated that patients who experience morning symptoms are at higher risk for exacerbations and are more likely to use their rescue inhaler. The diurnal variation in symptom severity has been observed during COPD exacerbations, with elevated risk for intubation during early morning hours in the emergency departmentConcentration related side effects dictate that serum concentration of Theophylline has to be maintained with in a narrow therapeutic range Frequent dosing – Limits its use and compliance Sustained release overcomes frequent dosing and decrease side effects. Study was planed compare the serum theophylline levels and clinical efcacy of once daily sustained release theophylline with standard dose on diurnal variation in chronic obstructive pulmonary disease. To determine, whether patients with COPD who are taking Theophylline thrice daily per day will be safely switched over to once daily dosage. To conrm whether the therapeutic concentration is maintained Evening dose theophylline is superior to morning dose in COPD in achieving clinical efcacy. Thrice daily dose does not achieve desired therapeutic level in all patients , sustained release had better therapeutic concentration but at same toxicity was more like palpitations compliance was better in sustained release tablets

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