DOI: 10.1039/d6bm01143h ISSN: 2047-4830

Chitosan–hyaluronic acid nanoparticles with time-dependent mucoadhesive and mucus penetrating behaviour to overcome pathological lung mucus

Marco Barretta, Francesca Della Sala, Giuseppe Marino, Mario di Gennaro, Gennaro Longobardo, Rubina Paradiso, Giorgia Borriello, Assunta Borzacchiello

Drug-free chitosan/hyaluronic acid nanoparticles resolve the mucosal retention-penetration trade-off via a time-dependent transition, combining dynamic mucus interaction with antioxidant, biocompatible, and intrinsic antimicrobial activity.

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