Chiroptical Imaging of Enantiomeric DNA Crystals
Akash Tiwari, Vidya R. Singh, Andrew Horvath, Jordan Janowski, Daniela Sanchez‐Giannakis, Simon Vecchioni, Yoel P. Ohayon, Ruojie Sha, James W. Canary, Bart KahrABSTRACT
The optical activity of enantiomorphous self‐assembled 3D DNA crystals was imaged. X‐ray structures of crystals assembled from L ‐ and D ‐nucleotides in the chiral space groups P 4 1 and P 4 3 , respectively, to 2.1–2.3 Å resolution, were analyzed using complete polarimetry to map circular birefringence. The crystals revealed optical activities of equal magnitude, but opposite sign as required by crystallographic symmetry. These results establish a solid‐state platform for quantitatively linking molecular chirality, crystal symmetry, and spatially resolved optical response.